Солиорлын эсрэг эмийн гаж нөлөөг эмийн эмчилгээний дэглэм баримтлах байдалтай харьцуулан судалсан дүн

Abstract

Background: Aminazine, an antipsychotic drug, was first used in the world in the 1950s, and atypical antipsychotic drugs began to be used in hospitals from the late 1980s. Schizophrenia is the most widely used disorder of antipsychotic drugs, and because of the side effects of conventional antipsychotic drugs in this disease, patients refuse drug therapy and do not adhere to drug therapy regimens. In our country, there have been some studies on the side effects of drugs, but there is no study on the side effects of antipsychotic drugs in patients with schizophrenia, which is the reason for conducting this study. Aim: To investigate the side effects of antipsychotic drugs in schizophrenic patients compared with adherence to drug treatment regimens. Materials and Methods: The study was conducted using a descriptive moment model, random sampling method, and a questionnaire survey from March 2023 to August 2023, based on ambulatory and clinics of the National Center for Mental Health. Ethical permission to conduct research was discussed and ethical permission was obtained on 03-02-2023 at the meeting of the Research Ethics Control Committee of MNUMS on February 17th, 2023, and the permission was obtained from the medical personnel through the consent form and attached to the research card. 5 groups of 36 questionnaires and the Glasgow standard test developed by the research team were used in the research. The results of the study were analyzed using Microsoft Word, Microsoft Excel, and STATA 14 software. Results: A total of 209 schizophrenic patients aged 18-79 participated in the study, 47.4% (n=99) were male and 52.6% (n=110) were female. 85.2% (n=178) had work disability due to schizophrenia. The side effects of medication observed by physicians were measured by the Glasgow standard questionnaire (Cronbach’s α=0.859) had 59.8% (n=125) of antipsychotic drugs had mild side effects, 38.8% (n=81) had moderate side effects, and 1.4% (n=3) had severe side effects. According to Morski’s standardized questionnaire, only 1.5% of patients adhere to medication regimens fairly well, and 98.5% have moderate or poor adherence (α=0.79). According to the Glasgow standard questionnaire, daytime sleepiness was reported in 68.9% (n=144; p=0.032), drug side effects were reported in 18.2% (n=38; p=0.053), dizziness on standing up, and signs of weakness in 56% (n=117; p=0.044), symptoms of movement and gait being slower than normal in 49.8% (n=104; p=0.024), blurred vision in 47.4% (n=99; p=0.040) was statistically significantly related to adherence to medication regimen. In the detailed evaluation of side effects, extrapyramidal side effects accounted for the highest percentage of 77.1%. Conclusions: The prevalence of some side effects of antipsychotic drugs can affect adherence to medication regimens. Among the side effects of antipsychotic drugs, extrapyramidal side effects account for the largest percentage, which is believed to be related to the fact that most of the patients with schizophrenia who participated in the study, 63.5%, use conventional drugs.