Evaluation of kidney dysfunction in the elderly using the Cockroft Gault equation

Abstract

Background: With age associated with physiological aging and concomitant chronic diseases, the pharmacokinetics of drugs such as drug absorption, distribution, metabolism and excretion change due to age-related changes in organ systems such as slowing metabolism, adaptation of physical activity and immunodeficiency. Aim: To study the degree of kidney function loss in elderly patients in a reference level hospital by evaluating the Cockcroft-Golt equation in relation to the use of drugs. Materials and Methods. The sample filtration rate (GER) decreases every 10 years by an average of 8 ml/min/1.73m2, so there is a need to regulate the dose of the drug depending on kidney function. In order to ensure proper and safe administration of the drug for the elderly, the priority is to determine the degree of renal dysfunction of the client and determine the appropriate dosage of the drug. Results: 88-year-olds were selected using a randomized sample, and drug use was carried out using a 44-question questionnaire and a single snapshot fact-based survey. Using the Cockroft-Gault equation to calculate the degree of renal dysfunction in adults, 39 (44.3%) of the population lost their degree, 20 (22.7%) of the population lost their Degree, 19 (21.6%) of the population lost their degree, 6 (6.8%) of the population lost their degree, and 4 (4.5%) of the population lost their degree. The prevalence of kidney dysfunction among the elderly requires a dose correction of the drug. Conclusion: 1. Determining the degree of renal dysfunction of the elderly hospitalized in the reference level hospital, 44.3% have grade I and 55.7% have grade II or higher renal dysfunction. 2. 39.7% of the elderly hospitalized in the referral hospital are using clopidogrel. 3. When comparing the medical treatment of the elderly according to the degree of renal dysfunction, 100% of the elderly using levofloxacin, aspirin, ketotifin, lisinopril and amitriptyline have renal dysfunction of grade II or higher.