To determine KIM1 marker people with kidney stone

Abstract

Background: According to the recent studies have shown that the KIM1 (kidney injury molecule-1) protein is secreted on renal proximal tubule epithelial cells of normal kidney and increased during acute and chronic kidney injury. According to a study by Matsuura et al., this finding may pave a way towards identifying KIM1 as a prognostic marker for kidney stone and kidney injury. In our country, the number of cases of kidney stones has been increasing in recent years. According to the researchers, evaluate the role of KIM-1 as a screening marker of kidney stone.KIM1 molecule affect the formation of kidney stones, and in this study. Aim: To investigate the investigate kidney function of people with kidney and urinary tract stones and to determine the KIM1 protein, a marker of kidney damage. Materials and Methods: We designed the study as a case-control study and 45 patients in the control group, 45 people in the control group were involved to analyses potassium, uric acid, urea, creatinine and ammonium. Serum was separated and was used to measure serum electrolytes, urea/creatinine levels by automation and KIM-1 levels by sandwich ELISA. Results: The KIM1 molecule level was 366.0±27.65 pg/ml in the kidney stone group and 356.8±17.93 pg/mlin the control group. There were no statistically significant differences between the case and control groups. When comparing KIM1 protein level with kidney stone size, it was 332.1±24.95 pg/ml in group with kidney stones up to 10 mm and 433.8±64.32 pg/ml in group with kidney stones larger than 10 mm, which is statistically significant (p<0.05).