The results of determining the candida fungus species in children of 0-2 ages with atopic dermatitis, and surveying the susceptibility to drugs

Abstract

Aim: This research aims at evaluating the severity index of atopic dermatitis, determining the candida types, and surveying the susceptibility of fungi to antifungal drugs. Materials and Methods: Our research was conducted using the snapshot research model covering 100 children with atopic dermatitis and 50 health children of 0-2 ages. Results: No fungus species are revealed in the healthy group. 50% of the children covered by the research were male and the rest of 50% were female. When evaluating the severity index of atopic dermatitis using the SCORAD score ranges, 23% of the children were mild, 37% - moderate, and 40% - severe. The fungus were not cultured in the moderate and severe cases, and the candida species fungi was cultured in 40% in the severe case, which shows that it worsens the illness process. 90% of total cultured fungus were C.albicans, and 10% were C.krusei. After determining the susceptibility of fungi to antifungal drugs, C.albicans was susceptible to fluconazole, voriconazole, caspofungin, micafungin, amphotericin B, and flucytosine, while C. krusei was resistant to fluconazole and flucytosine, and susceptible to voriconazole, caspofungin, micafungin, and amphotericin B. Conclusion: 1. It was determined that 40% of the respondents have severe atopic skin inflammatory disease. 2. C. albicans was detected in 90% of all children with severe atopic dermatitis, and C. krusei types were identified in 10%. 3. When determining the susceptible of antifungal drugs, C. albicans was susceptible to fluconazole, voriconazole, caspofungin, micafungin, amphotericin B, and flucytosine, while C. krusei was resistant to fluconazole and flucytosine, and susceptible to voriconazole, caspofungin, micafungin, and amphotericin B.