Identification of some factors influencing serum uric acid concentration in people with metabolic syndrome

Abstract

Background: Serum uric acid (SUA) levels are elevated in many disorders such as metabolic and cardiovascular disorders. Recent studies have documented that SUA levels are an early predictor of metabolic syndrome (MS), and individuals with hyperuricemia are 1.6 folds more likely to develop MS. Therefore, identifying SUA in people with MS can prevent other noncommunicable diseases and their related complications. Aim: determine SUA level in people with and without MS and to investigate factors influencing them Materials and Methods: 119 men aged 30-60 in Ulaanbaatar city were included. Hyperuricemia is defined as ≥7 mg/dl. Metabolic syndrome was defined using IDF and AHA/NHLBI criteria. Results: The prevalence of MS was 39.5% (n=47) and hyperuricemia was 16.8% (n=20). 21.3% (n=10) of men with MS had hyperuricemia. The mean SUA levels in the group without and with MS were 4.9±1.8 mg/dL and 6.2±1.3 mg/dL, respectively. For men without and with central obesity, SUA level was 4.7±0.8 mg/dL and 5.8±1.1 mg/dL (p<0.0001), respectively. The parameters significantly correlated with SUA were body weight (r=0.43), abdominal circumference (r=0.47), and triglycerides (r=0.44). Considering the group without MS vs with MS, there was a stronger relationship between parameters and SUA in the group without MS: body weight (r=0.48 vs r=0.24), abdominal circumference (r=0.5 vs r=0.36), and triglycerides (r=0.46 vs r=0.29). On the other hand, in the group with MS, SUA was correlated with abdominal circumference (r=0.36) and triglycerides (r=0.29). The risk of hyperuricemia increased with central obesity 3.27 times and triglycerides 3.29 times. Conclusion: 21.3% of participants with MS and 13.8% of participants without MS had hyperuricemia. Increased accumulation of abdominal fat and dyslipidemia can result in increased oxidative stress and SUA levels.