To analyse several metabolic characteristics in people with kidney stone

Abstract

Background: Nephrolithiasis is one of the most common diseases of the kidney and urinary system, and its incidence has increased in recent years. According to a study by Tilahun et al., 12 percent of the world’s population is at risk of developing nephrolithiasis, while 11 percent of the US population, or with an annual incidence of 1 case per 11 adults, and has kidney stones. In our country, the number of cases of kidney stones has been increasing in recent years. According to the researchers, some metabolic deficits affect the formation of kidney stones, and in this study, we aimed to investigate the correlation with metabolic parameters. Aim: To investigate changes in the chemical composition of stones and some metabolic parameters in patients with kidney stones compared to healthy people. Materials and Methods: We designed the study as a case-control study and 45 patients in the control group, 45 people in the control group were involved to analyses glucose, albumin, potassium, uric acid, urea, creatinine, ammonium, total protein, ALT, AST and total bilirubin. Results: Most stones are composed of calcium oxalate (76.7%) The results of the study showed that the body mass index, glucose, albumin, potassium, uric acid, urea, creatinine and ammonium was significantly different between the case and control groups. There were no statistically significant differences in total protein, ALT, AST and total bilirubin between case and control groups. Conclusions: 1. In terms of the chemical composition of kidney stones, calcium oxalate stones (76.7%) prevailed. 2. It was determined that there are changes in carbohydrate, mineral and protein metabolism in people with kidney stones.