Screening for heart failure with the natriuretic peptide test in people with diagnosed diabetes mellitus

Abstract

Background: One of the most significant risk factors for heart failure is diabetes, the prevalence of which is increasing year by year in worldwide. In recent years, studies have been conducted using N-terminal pro-B-type natriuretic peptide (NT-proBNP) to detect heart failure in patients with type 2 diabetes. However, in Mongolia, there has not been research on the detection of cardiovascular risk and heart failure based on the natriuretic peptide (NT-pro BNP). Aim: We aimed to identify the natriuretic peptide level and to assesscardiovascular risk inpatients with diabetes. Materials and Methods: In the current study, 70 individuals from 3 districtsin Ulaanbaatar city were selected according to inclusion criteria, cardiovascular risk factors were evaluated by questionnaire, anthropometric measurements were taken, HbA1C, high-density lipoprotein, total cholesterol, heart failure biomarker (NT-proBNP) were determined in fasting blood serum, and detailed urine analysis was performed. Participants were then assessed for CVD risk using the New Zealand 5-Year CVD Risk Calculator. Results: In 70 individuals who participated in the study, serum natriuretic peptide was determined by Getein 1100 quantitative immunofluorescence analyzer, in 9 cases or 12.8%, serum natriuretic peptide was higher than 125 pg/ml or positive. When assessing the risk of CVD in the next 5 years among the participants, 15.7% (11), 22.8% (16), 24.2% (17), 22.8% (16), and 14.2% (10) were at very low, low, moderate, high and very high risk, respectively. Among them, 17.6% (n=3) of modetrate-risk individuals, 12.5% (n=2) of high risk individuals, and 40% (n=4) of very high-risk individuals were positive for natriuretic peptide suggests that the relative higher incidence of positive NT-proBNP in high CVD-risk diabetic patients. Conclusion: 12.8% of study participants diagnosed with DMtype 2 had a positive natriuretic peptide test. People at high or very high CVD risk in the next 5 years had positive natriuretic peptide levels. There is a higher incidence of positive NT-proBNP in high CVD-risk diabetic patients, shows that a significant association between CVD risk and NT-proBNP.