Association between biomarkers of ovarian reserve and maternal age among infertility women

Abstract

Background: Ovarian reserve declines with maternal age and researchers have proposed a variety of biomarkers to determine ovarian reserve and function. Also, for couples diagnosed with infertility, the determination of ovarian reserve is an important predictor of pregnancy outcome. Therefore, researchers report that there is a need to specifically study the relationship between women’s age and ovarian reserve markers in women diagnosed with infertility. Aim: To study the relationship between age and biomarkers of ovarian reserve in maternal diagnosed with infertility Materials and Methods: The study was conducted in cross-sectional design from May 2021 to April 2022 at the National Center for Maternal and Child Health based on the Infertility and Reproductive Center. Maternal diagnosed with infertility were included in the study, and laboratory markers (Follicle stimulating hormone, Luteinizing Hormone, Estradiol, Antimuller hormone) were measured, and data were collected. Results: The study included 158 women aged 23-47 who were diagnosed with infertility, and the mean age was 33.6±5.3. The mean markers of the laboratory tests of the women included in the study were Follicle Stimulating Hormone 7.9±2.8, Luteinizing Hormone 7.9±2.84, Estradiol 43.2±6, and Anti-Mullerian Hormone 3.3±5.0. Women’s age was positively associated with Follicle-stimulating hormone (r=0.06, p=0.45) and Estradiol (r=0.009, p=0.9), by contrast Anti-Mullerian hormone (r=-0.23, p=0.005) had a statistically significant negative relationship. ANOVA test was revealed that AMH and FSH to age groups was different with p-value of 0.02. Conclusion: Ovarian reserve declines with age in women diagnosed with infertility, and biomarkers are measured with different efÏcacy. Ovarian reserve was significantly lower in women aged 40 and older who participated in the study.