Morphometric study on development of the urinary system and its some organ composition during fetal period

Abstract

Background: In recent years, there have been significant advances in prenatal diagnostic methods. Because of its implementation in clinical practice, there is need to update knowledge about anatomy and topography of organ systems, their morphological characteristics and peculiarities in the different fetal developmental stages. From the standpoint of morphogenesis and congenital malformations, reinvestigation of the gross anatomy and histology of urinary tract has a great clinical significance. During the fetal developmental stages there can be numerous abnormalities, such as changes in the size and location of the kidneys, duplication of the ureter also in ureter stricture and dilatation and symphysis pubis disorders. Therefore, the investigation of these urinary tract development problems is required. Aim: To determine the formation of urinary tract, its characteristics and tissue composition during human fetal development among Mongolians. Materials and Methods: Urinary tract organs, including kidneys in both the female and male human fetuses, were obtained at 14.9-32.9 weeks of gestational age without any abnormalities. Tissues were microdissected and histological methods was used to study its ultra structure. Measurements were done with Leica microsystems by using DISCUS program (version 3.2). Results: According to the macro morphometric parameters of the urinary system, including the kidneys, the process of their organogenesis have been investigated, and urinary organs were measured both gross anatomically and histologically. Conclusion: Fetal urinary organs have an asynchrone type of development between 14.9-32.9 weeks of gestational age.