The results of some studies made on Qingtang used in traditional medicine for hepatitis

Abstract

Background: Liver and gallbladder diseases are the leading causes of morbidity and mortality in our country, in which toxic hepatitis is the most common gastrointestinal disease. As of 2020, 341.4 cases of gastrointestinal diseases were registered per 10,000 population in Mongolia, of which liver diseases accounted for 23.2%, and liver and gallbladder cancer was one of the ten causes of death. According to Mongolian medical sources, Qingtang can relieve hepatic blood fever and is used for local pain around the liver, enlarged liver, hepatic haemorrhage, and jaundice. Aim: To study the effects of Qingtang on toxic hepatitis. Materials and Methods: The study was made with an experimental model in which 40 white mice (20±2 g) from the factory (KM) were randomly selected and divided into four groups (n=10): healthy group, pathogen model group, control group, and the experimental group to study toxicology and some pharmacological indicators. Results: The traditional Qingtang was less toxicity, LD50≥5g/kg. However, when H&E stained liver tissue microscopic images were compared, no lesions were found in the healthy group. However, large lesions were found in the pathogen model group, and when the results were compared to the experimental and positive control groups, the area of damage was significantly smaller or reduced. Moreover, hepatic coefÏcients, ALT, AST, SOD and MDA values statistical significance did not differ between the experimental group and the positive control group, but the AST/ALT mean of the positive control group was lower than that of the experimental group. Conclusion: Traditional Qintang recipes were less toxicity. Traditional Qintang has a liver protective effect or increases antioxidant activity.