Detection of non-thyroid ilness syndrome

Abstract

Background: International health organizations continue to warn of non-thyroid hormonal changes in some diseases, especially infectious diseases. In particular, recommendations need to be made to control the use of strong drugs during these temporary changes. Objective: To detect thyroid abnormalities and non-pathological thyroid hormones that occur during Covid-19 infection. Materials and Methods: The study was conducted by cross-sectional nd prospective designs between March 4 and March 24, 2022. The data of 189 participants treated at the Covid-19 inpatient department of the First State Central Hospital and the National Center for Infectious Diseases were analyzed, and the participants with changes were followed for 1 month. Results: The mean age of the respondents (n=124) was 51±17.3 and 60.4% (n=75) were women. Thyroid hormone changes occur in 40% of the study population. As Covid’s severity increases, TSH levels tend to decrease. In severe cases of Covid-19, the proportion of people whose TSH was below normal was 40%, and in mild cases it was 31.6%. Repeated tests after 30 days of no treatment showed that 68% (n=33) of those with hormonal changes had normal TSH levels. Conclusions: TSH changes are an important indicator of the severity of Covid-19, and thyroid disorders are common due to Covid-19. Covid-19 infection is characterized by non-thyroid TSH hormone changes, in which case it is best to discontinue antithyroid medication and follow up with control for 1 month.