Maternal vitamin D use during pregnancy and child respiratory disease

Abstract

Background: The amount of vitamin D in a child blood is directly related to the mother’s pregnancy. Researchers have suggested that childrens who used vitamin D during pregnancy could have a 2-3-fold lower risk of respiratory illness. However, there are few clinical studies that have identified a link between vitamin D use during pregnancy and respiratory illness in children. Aim: To study the relationship between maternal vitamin D use during pregnancy and child respiratory disease. Materials and Methods: The study was retrospectively based on the data of the “Randomized clinical trial of From Healthy Mother, Healthy Baby”. The mothers were registered at 12-14 weeks of gestation and randomly divided into 3 groups and given the test preparation. The study dose was 600 IU/day, 2000 IU/day and 4000 IU/day. Respiratory disease was measured by pneumonia (physician’s diagnosis) and tonsillitis (maternal history). Statistical analysis was performed using IBM SPSS 28.0. Results: The study included 313 pregnant women aged 18 to 43 years, and the ratio of the three study groups (600 IU, 2000 IU, 4000 IU) was 1:1:1. The risk of developing child tonsillitis was 18.9% higher in the group receiving vitamin IU 4000 than in group 4000 receiving vitamin D (B=1.18, 95.0% CI: 0.67 - 2.09). The risk of developing pneumonia in infants in a group of 600 doses of vitamin D per day was 1.6 times higher than in the group of doses of 4,000 IU per day. Conclusions: High maternal vitamin D intake during pregnancy reduces the risk of child pneumonia and tonsillitis.