Results of standardization study of the Musk raw material

Abstract

The musk, a biological secretion with unique odor, is produced by the Siberian musk deer (Moschus Moschiferus Linnaeus). Although in Traditional Mongolian Medicine, the musk was used to treat bacterial infectious diseases, it has not been conducted as standardized research till now. The aim of this study was to conduct standardization study and determine quality and safety parameters of Musk. The musk extracted from the musk deer domesticated in the “Musk deer breeding center of ITMT” was used for this study. Quality parameters (moisture, total ash) and safety parameters were determined by Mongolian National First Pharmacopoeia methods. The content of main biologically active compounds in the natural musk was determined by HPLC methods. Suitable condition of HPLC to reveal muscone in Natural Musk were defined and the content of muscone in Natural Musk was determined as 0.235±0.12%. Some quality and safety parameters of Natural Musk determined as: moisture 24.88±0.85%, total ash 2.62±0.32%, aerobic microbial, yeast and mould were not in the Musk. The standardization indicators of Natural Musk were defined and Mongolian national pharmacopoeia monograph’s draft for Natural Musk was developed.