Study result of clinical manifestations and pathogen of Herpangina

Abstract

Background: Herpangina (HA) is an acute respiratory infection, which is caused by enterovirus, in children aged 0-14 years old.1 It is characterized with fever and oral ulcers without any progression of vescular eruption on the skin. Enterovirus enters the host via the oral cavity and/or respiratory tract, then invades and replicates in the upper respiratory tract and small intestine, with a predilection for lymphoid tissues in the regions. Currently, there are no studies in Mongolia on the clinical signs and causative agents of herpangina, which has become the basis for our study. Aim: The aiming is to study correlation between the causative agents of herpangina and clinical symptoms in children aged 0-14 years in the Central Dental Hospital. Materials and Methods: 30 children diagnosed with Herpangina (ICD-10B08-5) at the Central Dental Hospital were included in the study in accordance with research ethics committee No.2020/3-05 and all experiments were performed by relevant guidelines and regulations. Samples of mucosal rash swabs and stools were analyzed by the Polio Laboratory of the National Center for Public Health. Results: The average age of children aged 2 months to 11 years old with diagnosis of HA was 3 years and 2 months old (95% CI: 2.4±0.1); fever developed in 80% of HA patients; the average temperature was 38.1±0.49 and 26.6% (8) patients developed symptoms of respiratory system (cough, runny nose and sore throat), 13.3% (4) patients developed symptoms of digestive system (bellyache, vomiting and diarrhea). On physical examination, 1-4 mm sized red macules were shown in 6.7% in oral cavity, vesicle and erosion in 16.7% and erosions in 76.6% (23). In the oral lesion, 37.5% on soft palate, 16.67% on isthmus fauces, 12.5% on combined position of soft palate and palatoglossal arch, 16.67% on soft palate and isthmus fauces, 16.67% on soft palate, palatoglossal arch and isthmus fauces. The fact that enterovirus was detected in 70% (21) of all children was statistically significant true probability (p<0.05). Conclusion: All children had symptoms of 87.5% fever and cough, runny nose, sore throat, bellyache, vomiting, and diarrhea. Herpangina case was defined as red spots, vesicle and erosion formed in soft palate, palatoglossal arch and isthmus of fauces. Therefore, after the laboratory analysis of swabs and stool samples, it is confirmed that herpangina is caused by enterovirus .