Results of PD-1/PD-L1 protein expression in renal cell carcinoma

Abstract

Introduction: In recent years, immunotherapy has become more widely used in the treatment of cancer. It has been noted that protein synthesis varies depending on the mechanism of renal cell carcinoma and ethnicity. Therefore, our research is based on the first determination of PD-1 / PD-L1 synthesis in kidney cancer tissue diagnosed in pathological practice in our country. Aim: To study the synthesis of PD-1 / PD-L1 protein in renal cell carcinoma in comparison with the pathological features and to determine the prognosis. Materials and Methods: Immunohistochemical staining was performed using PD-L1 (CD274, AHP-1703, BIO-RAD) and PD-1 polyclonal antibodies (CD279, AHP-1706, BIO-RAD) by preparing microarrays of 217 renal cell carcinomas. Results: Evaluation of sarcomatoid, rabdoid and tumor necrosis in renal cell carcinoma revealed significant differences in the presence of PD-L1 antibody positivity (p <0.05). Conclusions: Positive expression of PD-L1 / PD-1 protein is not related to the survival of renal cell carcinoma.