Changes in inflammatory biomarkers after stent placement in patients with acute myocardial infarction

Abstract

Objective: The objective of our study was to evaluate the impact of coronary angioplasty and stenting on inflammatory biomarkers in STEMI patients. Materials and Methods: The study included 60 patients who were implanted with 78 drug-eluting stents (drug-eluting stents (DES). Immediately before and 24 hours after, 1 month after, 1 year after implantation of the stent in the patient’s serum were determined: C-reactive protein by highly sensitive method (hsCKP), and theproinflammatory cytokines: tumor necrosis factor - alpha (TNF-a), interleukinIE-1, IE-6. Results: The results of the study showed that in 50% of all patients before surgery, the level of hypersensitivity CRP was more than 2 mg / l. After stent placement, high-sensitivity CRP increased statistically. No statistically significant changes in TNF or IL-1 levels were detected during stent placement. Conclusion: Coronary angioplasty and DES implantation were accompanied by an increase of inflammatory biomarkers (hsCRP, IE-6). Determination of markers of the inflammatory response in DES implantation may be useful to identify patients prone to a higher risk of complications after myocardial revascularisation, as well as for the prevention of ischemic events in the long term.