Literal review: the effect of folic acid and its analogy on differentiation and activation of osteoclast

Abstract

Folic acid is a water-soluble B vitamin and composed of pteridine, para-aminobenzoic acid, and glutamic acid. A vitamin or a small-molecule organic compound stimulates some molecules of adaptor or signal transduction through binding its specific receptor on the cell surface or nuclear. In addition to its involvement in DNA synthesis, folic acid has been shown to affect bone cell interactions, including osteoclast differentiation and activation. We have reviewed and analyzed a study of the effects of folic acid on osteoclast function. 1) NFATc1 and c-Fos transcription port factors play a key role in the study of the molecular mechanisms of osteoclast differentiation and activation. 2) In an overview of the effects of folic acid on osteoclasts in clinical and in vivo experiments, suggested that folic acid is involved in and inhibits osteoclast differentiation. 3) An overview of the effects of folic acid on osteoclastogenic signaling molecules suggests that folic acid may affect intracellular signaling by acting on cellular signaling proteins such as MAPK, NFκB, c-Fos, or by participating in cell oxidation-reduction reactions. However, it is unclear whether folic acid directly affects osteoclastic signal transduction.