Effect of GOYO-11 on the macro and micro structure of Nonsteroidal anti-inflammatory drug induced gastric ulcer

Abstract

Introduction: NSAIDs can be used to relieve pain, primarily to treat inflammation and reduce fever. By inhibiting cyclo-oxygenases (COX) NSAIDs block the formation not only of proinflammatory but also of gastroprotective prostaglandins. This is a key element in NSAID gastropathy as prostaglandins maintain gastric mucosal blood flow and increase protective mucus as well as bicarbonate production. The present study: pathological investigation on GOYO-11 and its derivatives in gastric mucosal damage induced by aspirin and this study aimed to investigate the effect of GOYO-11 on gastric ulcer. Methods: A total of 60 rats were divided into 6 groups. SD rats of male with body weight of 180-220 g were used for this study. Pure water 0.5 ml in the healthy group, aspirin 200 mg / kg in the control and treatment groups, omeprazole 4 mg / kg and De-nol 700 mg / kg in the standard drug group. After taking GOYO-11 (50, 100, 200 mg / kg) for 1 month, gastric tissue was removed and macro and micro structure was studied. Result: GOYO-11 herbal medicine, produced by traditional medicine technologies, has complex pharmacological activities including increased the number of gastric mucus cells and glandular reproductive cells, thickening the mucous membrane, intensifying mechanisms of acid secretion inhibition and cell protection, stopping bleeding,and decreasing wound area. These activities are related to the pathophysiology of cyclooxygenase enzyme which participates in prostaglandin synthase. Conclusion: GOYO-11 100mg/kg dose treated group showed significant good effect in micro and macro structure compared to standart drug group (DENOL and omeprazole).