Results of the CHRNA5 and CHRNA3 gene polymorphisms in chronic obstructive pulmonary disease

Authors

  • Б.Агарзандан Биологийн тэнхим, Био-Анагаахын Сургууль, АШУҮИС Author
  • Ж.Жамбалдорж Молекул биологи – Удамзүйн тэнхим, Био-Анагаахын Сургууль, АШУҮИС Author
  • Г.Чимэдлхамсүрэн Молекул биологи – Удамзүйн тэнхим, Био-Анагаахын Сургууль, АШУҮИС Author
  • П.Одончимэг Уушгины эмгэг судлалын тасаг, ШУГТЭ Author
  • Ж.Сарантуяа Молекул биологи – Удамзүйн тэнхим, Био-Анагаахын Сургууль, АШУҮИС Author

Keywords:

Nicotinic acetylcholine receptor, single-nucleotide polymorphism

Abstract

We have involved 100 COPD case, 100 control subjects using case-control of analytic study. Determination of CHRNA5 and CHRNA3 gene polymorphisms were performed by PCR-RFLP (Polymerase Chain Reaction - Restriction Fragment Length Polymorphism) method. A comparative study of the alleles and genotype frequencies of the polymorphism of the CHRNA5 gene rs16969968 and the CHRNA3 gene rs1051730 revealed statistically significant differences between the two study groups.

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Author research profiles: Б.Агарзандан, Ж.Жамбалдорж, Г.Чимэдлхамсүрэн

Боть 17, №4 (60) 2021

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Published

2021-03-21

Issue

Vol. 17 No. 4 (2021)

Section

Original Articles

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Articles in this journal are published under the Creative Commons Attribution 4.0 International License (CC BY 4.0). Anyone may copy, distribute and adapt the work, provided the authors and the source are properly credited. Copyright remains with the authors.