The efÏcacy and safety of Insulin therapy

Abstract

Introduction: In the 100 years since the discovery of insulin, insulin types, forms, and injection techniques have been improved year by year to increase its effectiveness and safety. In our country, the efÏcacy and safety of insulin therapy have not yet been studied. Materials and Methodology: The study involved a total of 262 people with diabetes who used insulin under control of an endocrinologist in three districts of Ulaanbaatar by cross-sectional descriptive study. Data were collected through questionnaires. Result: 47.3% (n=124) of the participants were male, with an average age of 52.4±12.9. 78.2% (n=205) of people with diabetes use recombinant human insulin, and 21.8% (n=54) use analog insulin. Glucose variability are higher in people using human insulin (p<0.05). Insulin-related hypoglycemia was detected in 30.5% (n=80) of people with diabetes. Regression analysis have shown that factors may increase the risk of hypoglycemia include excessive glucose variability and daily insulin doses. Conclusion: The effectiveness of insulin therapy depends on its form, and glucose variability are lower in people using analog insulin. Inadequate glucose control increases the risk of hypoglycemia.