Effect of Astragalus Mongholicus bunge on immobilization stress induced anxiety in rats

Abstract

Background: According to the WHO, globally as of 2019 approximately 273 million (4.5% of the population) had an anxiety disorder. Astragalus mongholicus Bunge (AM) is Russia, Mongolia, Kazakhstan, and China are the most natural distribution areas of AM within the world. However, the standard of medicinal plant varies among different locations. Therefore, the present study aimed to investigate the antidepressant effect of the roots of AM cultivated in Mongolia. Method: Thirty rats randomly divided into six groups were used for the evolution. The animals were immobilized for 12 hours by tying four limbs in a horizontal position. At the end of the experiment, the weight of the thymus gland and adrenal glands was measured and gastric bleeding was determined. Furthermore, serum cortisol levels were determined by ELISA. Results: The AM 284 mg/kg group reduced the size of the thymus gland by 44.5%, and AM 142, 284 mg/kg group adrenal gland enlargement by 33.39% compared to the control group (p<0.05). Administration of AM (142 mg/kg) the decreased serum cortisol levels (p<0.05). Conclusion: In conclusion, results from the present study showed that AM could prevent immobilization stress induced thymus gland and adrenal gland enlargement in rats as well as reduce the concentration of cortisol.