The effect of Mongolian garlic ( Allium sativum L ) extract against a gastric ulcer

Abstract

The aim of this study investigate the anti-ulcer effect of Mongolian garlic (Allium sativum L) extract in acetic acid induced gastric ulcer in rats. The garlic cloves crushed and mixed with 70% ethanol (ratio 1:2). The obtained dry extract from lyophilized in garlic extract. Twenty seven male Wistar rats were experimented. The rats were divided into three groups:first group (garlic extract 250mg/kg, n=9 ), second group (garlic extract 500mg/kg, n=9), third group control (distilled water n=9).The 7,14 and 21 days later the rats were sacrificed and gastric tissue healing was evaluated histophatologically. Both the doses of garlic extract showed gastric ulcer healing effect in rats after 7 and 14 days and gastric ulcer was regenerated by new healty cells in all level treated well after 21 days. The results of this study show that Mongolian garlic extract is effective accelerating gastric ulcer healing process and improving regeneration.