Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in diabetes patients

Abstract

Background. Type 2 diabetes mellutis (T2DM) is a chronic disease characterized by hyperglycemia. Neutrophil to lymphocyte ratio (NLR) and Platelet to lymphocyte ratio (PLR) are important markers used in the diagnosis of general inflammatory conditions in the human body. It is stated that NLR and PLR are cheap and easily calculable markers that correlate with the prognosis of chronic inflammatory and are frequently used in laboratories. Aims: Investigate the relationship between NLR and PLR; which are among the parameters of complete blood count (CBC) and T2DM. Material and methods. A cross-sectional study included 50 participants in each group; maintaining a 1:1 ratio between those diagnosed with T2DM and the non-diabetic group. Relationships and differences between the patient and non-deabetic groups were investigated. The CBC tests (includes neutrophil, lymphocyte and platelet) were performed on the Sysmex-XN2000 hematology analyzer. For the statistical analysis of the data obtained from the studies; the SPSS-29 program was used. Results: The geometric mean age of T2DM patients were 54.65 and non-deabetic group was determined as 51.2. There was no significant difference between the patient and control groups in terms of age and gender. The NLR of T2DM patients was 2.45±1.21 and that of the non-deabetic group was 1.51±0.79. The PLR of T2DM patients was 165.29±57.67 and that of the non-deabetic group was 119.21±49.73. When NLR and PLR values of T2DM patients and the control group were compared, it was found that it was statistically significant (p<0.05). Conclusion: The high and statistically significant NLR and PLR values in patients revealed that these parameters are essential in diagnosing and following T2DM disease. Therefore; it may be required to establish the connection between the pathogenesis of T2DM and the NLR and PLR.