Case of Wegener’s granulomatosis

Abstract

Introduction: Granulomatosis with polyangiitis (GPA),also known as Wegener's granulomatosis (WG) is an extremely rare long-term systemic disorder that involves formation of Giant-Cell granulomas and inflammation of blood vessels (vasculitis) of several organ systems and thought to be induced by immune or autoantibody (ANCA - antineutrophil cytoplasmic antibodies) and associated with toxicity and allergy (1). Initially involves the upper (nasal sinuses -panvasculitis 85%), pharynx and larynx), lower respiratory (trachea, bronchi and alveoli) tracts and kidney and later involves esophagus, stomach and intestines. Peribronchial scar tissue and stenosis usually result in atelectasis and pneumonia (2). Case presentation: We describe a 37-year-old, man who presented with cough, haemoptysis and pleurisy in both side of chest. Cough and dyspnoea is stimulated minor movements. Bloody and exudative rash is in the skin of bilateral elbows, legs and thighs. Immunology: PR3-cANCA positive-5.23 э