Effect of musk on Arg-1 protein content

Abstract

Introduction: In recent years, there has been a significant increase in cerebrovascular disease in the world and in Mongolia, which is the second leading cause of death. The current study aimed to investigate the effect of musk on neurological function due to cerebral ischemia/reperfusion in rats. Materials and methods: Cerebral middle cerebral artery occlusion was established in male rat (90-minute occlusion followed by 24-hour reperfusion). Rats were divided following groups: control group, ischemia (cerebral ischemia and reperfusion), nimodipine (cerebral ischemia and reperfusion + every day treatment of nimodipine), musk 50 mg/kg (cerebral ischemia and reperfusion + every day treatment of musk doses of 50 mg/kg), musk 100 mg/kg (cerebral ischemia and reperfusion every day treatment of musk doses of 50 mg/kg for 7 days). The expression level of Arg-1 was detected using immuno uorescence staining. Results: Treatment with 50 mg/kg and 100 mg/kg for 1, 3, 7 days significantly improved neurological function, and increased the expression levels of Arg-1 in the ischemic hemisphere of brain in rats. Conclusion: The mechanisms of musk are associated with increasing the expression levels of Arg-1, and subsequently stimulating neurogenesis and reduced ischemic zone. fl