The study of trans epidermal water loss in children with atopic dermatitis

Abstract

Introduction: The first signs and symptoms of Atopic dermatitis usually occurs in early childhood. Atopic dermatitis is a chronic relapsing inflammatory skin disease characterized by xerosis and highly pruritic. In the Elias and Taieb were among the first to suggest that the breakdown of the skin barrier may be an initial event in the development of Atopic Dermatitis. Study shown Loss of skin moisture, trans-epidermal water loss (TEWL) was caused by Impaired skin barrier in atopic dermatitis. Curently in Mongolia no studies have been performed to evaluate the parameters of the skin of children with atopic dermatitis. Purpose: Evaluating trans epidermal water loss on children with atopic dermatitis. Materials and methods: Fifty-five Mongolian patients with AD, age range of 0-19 years, affected by AD according to the criteria of Hanifin and Rajka and 38 healthy age-matched children were included in this study. AD disease severity was determined by using the SCORing Atopic Dermatitis (SCORAD) index and skin surface TEWL was measured by skin multiprobe system tewameter TM 210+Courage (Khazaka electronic GmbH, Ko In, Germany). Results: For skin surface TEWL statistically significant differences between the groups were found (p<0.05). Overall lesional skin surface average TEWL was 11.08 (gm2\ per hour) non lesional was 6.1(gm2\ per hour) and healthy control was 6.8(gm2\ per hour). Conclusion: When evaluating TEWL of the participants, lesional skin area of children with ad shows highest value. However non lesional skin area of children with ad shows same value as healthy children.Thus we concluded TEWL might be related to climate conditions of Mongolia.