Association between air pollution and detection of allergic asthma by mannitol challenge test

Abstract

Background: There are 339 million people with asthma globally, about 1 in 20 of the world’s population1. In 2010, prevalence of asthma among 6-7 years old children is 20.9% and current asthma is 15.8%, physician diagnosed asthma is 4.7% among adults in our country2. We have a possibility to detect asthma earlier with airways hyperresponsiveness by the bronchial challenge test. Aim. The main aim this study was to defined association between air pollution and detection of airways hyperresponsiveness by mannitol challenge test. Method and materials: We were detected 40 different allergen-scpecific IgE by the automated microfluidic-based immunoassay system (Agnitio Technology and Sciences Inc, Taiwan) and for detection of airway ventilation function by the spirometry (Spirostar USB, Spiro pro 3.1.2 software Medikro OY). Mannitol challenge tests were used 9 steps protocol (Aridol/Osmohale, Pharmaxis Ltd Frenchs Forest, Sydney Australia) and cumulative doses was increased 635 mg. We were evaluated the significant decreasing of FEV1 was 15%. Air pollution parameters were used from the Agency for meteorological and environmental of Mongolia Results: We were chosen 196 subjects with 18-69 years old (mean age 32±8.8, 95%CI: 23.4–49.6) 95 males and 101 females. There was statistically significant decreased 43.2±8.9% of postFEV1 than preFEV1 parameters by the mannitol challenge test. The mean cumulative dose of mannitol in airways was 253±17 mg during positive results in mannitol challenge test. We were noticed association of positive correlation between winter season and hyperresponsiveness of lower airways. Conclusion: Bronchial hyperresponsiveness were associated with winter season and weeds pollination period of time.