Comparison of Monocytes/HDL ratio with cardiovascular risk factors

Abstract

Background: Monocyte /High Density Lipoprotein Ratio (MHR) has become a nailew diagnostic marker that used determining the inflammation during the cardiovascular diseases and is a handy and reliable diagnostic marker at a low cost. Objectives: The MHR should be compared with cardiovascular risk factors, evaluate correlation, and the possibility of using CVD as a marker of early detection of inflammation should be investigated. Methods: Between October 2019 to December 2019, this hospital-based cross sectional study was done. Employees of organizations undergoing preventive examinations were involved in this cross sectional study. The study included 20-75 year olds with no clinical signs of cardiovascular disease according to certain criteria. Of the total 376 people aged 20-64, 263 were aged 20-39 and 113 were aged 40-64. Significant indicators were identified by comparing cardiovascular risk factors with the MHR. For example, the MHR was 13.01±5.05 in the smoking group, 9.19±4.11 in the non-smoking group, and the MHR was 7.88±3.30 and 12.82±4.89 in the non-smoker group, and there were statistically significant differences (p <0.05). The MHR in the low, high, and very high groups were significantly different from 9.40±4.72, 8.83±3.45, and 12.01±5.12 when estimating the survival risk of CVD in the 20-39 age group. When evaluating the 10-year risk of CVD for 40-64 year olds using the Cohort equation method, the MHR were 9.02±3.68, 13.99±5.24, 14.16±5.19 in the low, medium, and high groups, and there were significant differences between the groups (p <0.05). Conclusions: MHR was significantly correlated with cardiovascular diseases risk factors such as smoking, arterial hypertension, alcohol abuse, working conditions, obesity, and dyslipidemia. The increase in the 10-year risk of cardiovascular diseases and the proportion of survival risk increased with the MHR, indicating that it could be used as a marker of CVD inflammation.